N-Caffeoyl O-methyltyramine

Name: N-Caffeoyl O-methyltyramine
Brand: MedChemExpress
SKU: HY-N7203
Rating: 4.5 (1 reviews)

Cat. No.: HY-N7203 Purity: 98.44%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC₅₀ of 103.58 μM).

For research use only. We do not sell to patients.

N-Caffeoyl O-methyltyramine Chemical Structure

CAS No. : 189307-47-9

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 110	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 110	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 900	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of N-Caffeoyl O-methyltyramine:

N-Caffeoyl O-methyltyramine (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC₅₀ of 103.58 μM)^[1].

IC₅₀ & Target

IC50: 103.58 μM (α-glucosidase)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	> 10 μM Compound: 5	Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 3 days by SRB assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 3 days by SRB assay	[PMID: 23327794]

Molecular Weight

313.35

Formula

C₁₈H₁₉NO₄

CAS No.

189307-47-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCC1=CC=C(OC)C=C1)/C=C/C2=CC=C(O)C(O)=C2

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (797.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1913 mL	15.9566 mL	31.9132 mL
5 mM	0.6383 mL	3.1913 mL	6.3826 mL
10 mM	0.3191 mL	1.5957 mL	3.1913 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.44%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (244 KB) HNMR (257 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Anis E, et al. Alpha-glucosidase inhibitory constituents from Cuscuta reflexa. Chem Pharm Bull (Tokyo). 2002 Jan;50(1):112-4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1913 mL	15.9566 mL	31.9132 mL	79.7830 mL
	5 mM	0.6383 mL	3.1913 mL	6.3826 mL	15.9566 mL
	10 mM	0.3191 mL	1.5957 mL	3.1913 mL	7.9783 mL
	15 mM	0.2128 mL	1.0638 mL	2.1275 mL	5.3189 mL
	20 mM	0.1596 mL	0.7978 mL	1.5957 mL	3.9891 mL
	25 mM	0.1277 mL	0.6383 mL	1.2765 mL	3.1913 mL
	30 mM	0.1064 mL	0.5319 mL	1.0638 mL	2.6594 mL
	40 mM	0.0798 mL	0.3989 mL	0.7978 mL	1.9946 mL
	50 mM	0.0638 mL	0.3191 mL	0.6383 mL	1.5957 mL
	60 mM	0.0532 mL	0.2659 mL	0.5319 mL	1.3297 mL
	80 mM	0.0399 mL	0.1995 mL	0.3989 mL	0.9973 mL
	100 mM	0.0319 mL	0.1596 mL	0.3191 mL	0.7978 mL