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Cysteine Targeted Covalent Library

Cat. No.: HY-L153

Covalent inhibitors are small molecules that can bind specifically to target proteins through covalent bonds and inhibit their biological functions. Although for a long time, covalent targeting has been playing a subordinate role in drug discovery, with an increasing number of reports on successful clinical applications of such drugs, the potential of these agents is now being acknowledged. Currently, cysteine is the most common covalent amino acid residue in a variety of covalent drugs, and various warheads have been developed that can react with cysteine, providing the key building blocks for covalent drugs to form covalent bonds.

To meet the development needs of covalent inhibitors targeting cysteine, MCE has designed a unique collection of 4,845 compounds with different covalent warheads that target cysteine. The MCE Cysteine Targeted Covalent Library is designed using the following covalent warheads: Acrylamides, Propiolic acid ester, Dimethylamine functionalized acrylamides, Chloroacetamides, Acrylonitrile, 2-Cyanoacrylamide, Aziridine, Haloacetamide, etc.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Description & Advantages

•   A unique collection of 4,845 compounds with different covalent warheads that target cysteine.

•    Contains various covalent warheads targeting cysteine residue.

•   Compounds were pre-filtered with the Rule of Five restrictions: MW 150 – 500; ClogP ≤ 5; H-donors ≤ 5; H-acceptors ≤10; Rotatable bonds ≤ 10.

•   A useful tool for development covalent drugs.

•   Validated NMR and HPLC to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details

Formulation:

A collection of 4,845 compounds with different covalent warheads that target cysteine supplied as pre-dissolved Solutions or Solid.
Solution: 4,819 compounds supplied in 10 mM solution, 6 compounds supplied in 2 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

Composition

EGFR (41)

Btk (19)

Akt (15)

COX (12)

JAK (11)

STAT (11)

Ras (9)

IRE1 (5)

PI3K (5)

YAP (5)

ERK (4)

HDAC (4)

HIV (4)

JNK (4)

MMP (4)

mTOR (4)

CDK (3)

FGFR (3)

HSV (3)

KLF (3)

PKC (3)

Smo (3)

SphK (3)

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  •  Form (Solid or Solution)
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    Product Name:
    Cysteine Targeted Covalent Library
    Cat. No.:
    HY-L153
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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