2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage
  3. Endogenous Metabolite PPAR
  4. N-Octadecyl-N'-propyl-sulfamide

Peroxisome proliferator-activated receptors (PPARs) play an important role in regulating lipid and glucose metabolism, and oleoylethanolamide (OEA) is a natural ligand for PPARα. N-Octadecyl-N'-propyl-sulfamide is an analog of OEA and a potent activator of PPARα, with selective binding affinity for PPARα (EC50=100 nM, compared to 120 nM for OEA). N-Octadecyl-N'-propyl-sulfamide (10 mg/kg; ip) inhibits food intake and reduces body weight gain in rats. At a dose of 1 mg/kg, N-Octadecyl-N'-propyl-sulfamide induces satiety, thereby reducing food intake, body weight, and plasma triglyceride concentrations in free-feeding Wistar rats and obese Zucker (fa/fa) rats.

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N-Octadecyl-N'-propyl-sulfamide Chemical Structure

N-Octadecyl-N'-propyl-sulfamide Chemical Structure

CAS No. : 925891-74-3

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N-Octadecyl-N'-propyl-sulfamide Related Antibodies

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Description

Peroxisome proliferator-activated receptors (PPARs) play an important role in regulating lipid and glucose metabolism, and oleoylethanolamide (OEA) is a natural ligand for PPARα. N-Octadecyl-N'-propyl-sulfamide is an analog of OEA and a potent activator of PPARα, with selective binding affinity for PPARα (EC50=100 nM, compared to 120 nM for OEA). N-Octadecyl-N'-propyl-sulfamide (10 mg/kg; ip) inhibits food intake and reduces body weight gain in rats. At a dose of 1 mg/kg, N-Octadecyl-N'-propyl-sulfamide induces satiety, thereby reducing food intake, body weight, and plasma triglyceride concentrations in free-feeding Wistar rats and obese Zucker (fa/fa) rats.

IC50 & Target

PPARα

 

Molecular Weight

390.67

Formula

C21H46N2O2S
CAS No.
SMILES

CCCCCCCCCCCCCCCCCCNS(=O)(NCCC)=O
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N-Octadecyl-N'-propyl-sulfamide Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Octadecyl-N'-propyl-sulfamide925891-74-3Endogenous MetabolitePPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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