1. Metabolic Enzyme/Protease Apoptosis NF-κB Immunology/Inflammation
  2. NAMPT Apoptosis Reactive Oxygen Species
  3. Nampt-IN-8

Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS.

For research use only. We do not sell to patients.

Nampt-IN-8 Chemical Structure

Nampt-IN-8 Chemical Structure

CAS No. : 2453183-75-8

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Description

Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS[1].

IC50 & Target

IC50: 0.183 μM (NAMPT)[1]

Cellular Effect
Cell Line Type Value Description References
A549 IC50
1.15 μM
Compound: 10d
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
A549/TR IC50
11.82 μM
Compound: 10d
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
A549/TR IC50
124.9 μM
Compound: 10d
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide, dicumarol, N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminesce
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide, dicumarol, N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminesce
[PMID: 35640078]
A549/TR IC50
14.48 μM
Compound: 10d
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with NQO1 inhibitor, dicumarol followed by compound addition and measured after for 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with NQO1 inhibitor, dicumarol followed by compound addition and measured after for 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
A549/TR IC50
4.1 μM
Compound: 10d
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
A549/TR IC50
45.29 μM
Compound: 10d
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
L02 IC50
120.4 μM
Compound: 10d
Antiproliferative activity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
In Vitro

Nampt-IN-8 (Compound 10d) shows antiproliferative activity with an IC50 of 1.15 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nampt-IN-8 (Compound 10d) (0-20 mg/kg) substantially inhibits the growth of A549/taxol xenograft tumors in vivo with no significant toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

573.68

Formula

C36H35N3O4

CAS No.
SMILES

O=C1C2=C(CCCC3(C)C)C3=CC=C2C4=C(C1=O)C(C)=C(O4)CNC5=CC=C(C=C5)CCNC(/C=C/C6=CN=CC=C6)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Nampt-IN-8
Cat. No.:
HY-147795
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