2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. NAS-181

NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions.

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NAS-181 Chemical Structure

NAS-181 Chemical Structure

CAS No. : 205242-62-2

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NAS-181 Related Antibodies

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Description

NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions[1].

In Vitro

NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices[1].
NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NAS-181 Related Antibodies
In Vivo

NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 20 mg/kg
Administration: S.c.
Result: Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40−60%).
Molecular Weight

442.53

Formula

C20H30N2O7S
CAS No.
SMILES

CS(=O)(O)=O.[C@H]1(COC2=C3C(C=C(CN4CCOCC4)CO3)=CC=C2)CNCCO1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NAS-181 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAS-181205242-62-2NAS181NAS 1815-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HTP accumulationbrain regionswet dog shakesp-chlorophenylalanineInhibitorinhibitorinhibit

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HY-135507
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