NDT-30805

Cat. No.: HY-150965: FAQs
Data Sheet Handling Instructions

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NDT-30805 is a selective NLRP3 inflammasome inhibitor. NDT-30805 is a triazolopyrimidinone derivative and inhibits IL-1β release in PBMCs with an IC₅₀ of 0.013 μM. NDT-30805 can be used for the research of inflammation and innate immunity.

For research use only. We do not sell to patients.

NDT-30805 Chemical Structure

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NLRP3 NLRP1 NOD1 NOD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

NLRP3

NLRP3 inflammasome

In Vitro

NDT-30805 (0-2 μM; 30 min) inhibits IL-1β release in PBMCs^[1].
NDT-30805 (0-2 μM; 30 min) inhibits ASC speck formation in THP1-ASC-GFP cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Human PBMCs
Concentration:	0-2 μM
Incubation Time:	30 min
Result:	Inhibited IL-1β release in PBMCs with an IC₅₀ of 0.013 μM.

Cell Viability Assay^[1]

Cell Line:	THP1-ASC-GFP cells
Concentration:	0-2 μM
Incubation Time:	30 min
Result:	Inhibited ASC which is a component of NLRP3 inflammasome in PBMCs with an IC₅₀ of 0.034 μM.

Molecular Weight

414.53

Formula

C₂₃H₂₂N₆S

SMILES

S=C1C=C(CC2=NC=CC=C2)NC3=NC(NC4=C5CCCC5=CC6=C4CCC6)=NN13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. David H, et al. Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors. ACS Medicinal Chemistry Letters. 2022. [Content Brief]

NDT-30805 Related Classifications

Inflammation/Immunology

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NDT-30805NDT30805NDT 30805NOD-like Receptor (NLR)inflammasomeinterleukin-1inflammationinnate immunityInhibitorinhibitorinhibit

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