2. Anti-infection
  3. SARS-CoV
  4. Nepuvibart

Nepuvibart  (Synonyms: ZRC3308-B10)

Cat. No.: HY-145643

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Nepuvibart (ZRC3308-B10) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Nepuvibart shows good binding affinity to a non-competing epitope on the RBD of the SARS-CoV-2 spike protein. Nepuvibart can be used in combination with ZRC3308-A7 (HY-145642) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease.

For research use only. We do not sell to patients.

CAS No. : 2640224-48-0

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Description

Nepuvibart (ZRC3308-B10) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Nepuvibart shows good binding affinity to a non-competing epitope on the RBD of the SARS-CoV-2 spike protein. Nepuvibart can be used in combination with ZRC3308-A7 (HY-145642) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
IC50 & Target

SARS-CoV-2[1].
In Vitro

Nepuvibart (ZRC3308-B10; 0-5×105 ng/mL) shows virus neutralizing ability in VeroE6/Vero CCL81 (SARS-CoV-2 infection model) cells, when in combination with ZRC3308-A7 (ratio 1:1)[1].
Nepuvibart neutralizes SARS-CoV-2 variants B.1.1.7, B.1.351, B.1.617.2, and B.1.617.2AY.1 in vitro, when in combination with ZRC3308-A7 (ratio 1:1) [1].
Nepuvibart binds to the RBD of SARS-CoV-2 S1 protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nepuvibart Related Antibodies

Cell Viability Assay[1]

Cell Line: VeroE6/Vero CCL81 cells (SARS-CoV-2 infection model)
Concentration: 0-5×105 ng/mL (in combination with ZRC3308-A7)
Incubation Time: 72 h
Result: Showed potent neutralization activity with an IC50 of 0.1283 ng/mL.
In Vivo

Nepuvibart (ZRC3308-B10; 0.5, 2.5, 25 mg/kg; 48 h prior to the SARS-CoV-2 infection) effectively prevents SARS-CoV-2 infection in syrian hamster, when in combination with ZRC3308-A7 (ratio 1:1)[1].
Nepuvibart (0.5, 2.5, 25 mg/kg; i.p.; single) shows the serum levels remaines constant without much reduction for up to 7 days, in syrian hamster [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female syrian hamster (7 to 10-week-old; SARS-CoV-2 infection model)[1].
Dosage: 0.5, 2.5, 25 mg/kg
Administration: Intraperitoneal injection; 48 h prior to the SARS-CoV-2 infection
Result: Prevented SARS-CoV-2 infection when in combination with ZRC3308-A7.
CAS No.
SMILES

[Nepuvibart]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Nepuvibart Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nepuvibart2640224-48-0ZRC3308-B10SARS-CoVSARS coronavirusCOVID-19RBDVeroE6/Vero CCL81 cellInhibitorinhibitorinhibit

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