Neuroinflammatory-IN-3 

Neuroinflammatory-IN-3, a tubulin inhibitor, is an anti-neuroinflammatory agent. Neuroinflammatory-IN-3 is a potent antitumor agent that functions by the inhibition of tubulin polymerization_[1]^[2].

Neuroinflammatory-IN-3 (compound 1) inhibits LPS-mediated NO release in BV-2 microglial cells down to 70% at a 10 μM concentration, with an IC₅₀ of 5.22 μM. Neuroinflammatory-IN-3 binds to the Colchicine-binding domain of tubulin^[1].
Neuroinflammatory-IN-3 (compound 1; 72 hours) is antiproliferative toward HeLa, U266, A549, and MCF7 cell lines with IC₅₀ values of 450 nM, 416 nM, 381 nM, and 744 nM, respectively_[2].
Neuroinflammatory-IN-3 (compound 1; 1 μM; 3-12 hours) triggers cell-cycle arrest in a time-dependent manner^[2].
Neuroinflammatory-IN-3 (compound 1) inhibits tubulin polymerization in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

330.81

C₁₉H₁₉ClO₃

1202404-23-6

OC1=C(OC)C=CC2=C1OC(C)(C)C=C2C3=CC=C(Cl)C=C3C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Junhyeong Yim, et al. Phenotype-based screening rediscovered benzopyran-embedded microtubule inhibitors as anti-neuroinflammatory agents by modulating the tubulin-p65 interaction. Exp Mol Med. 2022 Dec 12;1-10  [Content Brief]

  [2]. Jongmin Park, et al. Discovery and target identification of an antiproliferative agent in live cells using fluorescence difference in two-dimensional gel electrophoresis. Angew Chem Int Ed Engl. 2012 May 29;51(22):5447-51.  [Content Brief]