2. GPCR/G Protein
  3. Apelin Receptor (APJ)
  4. NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)

NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) (compound 39) is a potent APJ agonist, with a Ki of 0.6 nM. NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) can activate Gαi1 (EC50=0.8 nM) and recruit β-arrestin2 (EC50=31 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) exhibits prolonged cardiac effects.

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NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) Chemical Structure

NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) Chemical Structure

CAS No. : 2891469-80-8

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NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) Related Antibodies

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Description

NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) (compound 39) is a potent APJ agonist, with a Ki of 0.6 nM. NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) can activate Gαi1 (EC50=0.8 nM) and recruit β-arrestin2 (EC50=31 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) exhibits prolonged cardiac effects[1].

IC50 & Target

APJ[1]
Molecular Weight

1020.18

Formula

C49H73N13O11
CAS No.
SMILES

N[C@@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N2CCC[C@H]2C(N[C@H](CC3=C4C=CC=CC4=CC=C3)C(O)=O)=O)=O)=O)CCCCN)=O)C/C=C\C1)=O)CO)=O)CC(C)C)=O)CCCNC(N)=N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
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NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) Related Classifications

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Keywords:

NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)2891469-80-8Apelin Receptor (APJ)APJGαi1β-arrestin2cardiac effectInhibitorinhibitorinhibit

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