2. PROTAC
  3. PROTAC Linkers
  4. NH2-C6-NH-Boc

NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC.

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NH2-C6-NH-Boc Chemical Structure

NH2-C6-NH-Boc Chemical Structure

CAS No. : 51857-17-1

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Based on 1 publication(s) in Google Scholar

NH2-C6-NH-Boc Related Antibodies

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Description

NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC[1].

Molecular Weight

216.32

Formula

C11H24N2O2
CAS No.
Appearance

Solid-Liquid Mixture

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)NCCCCCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (462.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6228 mL 23.1139 mL 46.2278 mL
5 mM 0.9246 mL 4.6228 mL 9.2456 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.61%

SDS (476 KB)

COA (241 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 4.6228 mL 23.1139 mL 46.2278 mL 115.5695 mL
5 mM 0.9246 mL 4.6228 mL 9.2456 mL 23.1139 mL
10 mM 0.4623 mL 2.3114 mL 4.6228 mL 11.5570 mL
15 mM 0.3082 mL 1.5409 mL 3.0819 mL 7.7046 mL
20 mM 0.2311 mL 1.1557 mL 2.3114 mL 5.7785 mL
25 mM 0.1849 mL 0.9246 mL 1.8491 mL 4.6228 mL
30 mM 0.1541 mL 0.7705 mL 1.5409 mL 3.8523 mL
40 mM 0.1156 mL 0.5778 mL 1.1557 mL 2.8892 mL
50 mM 0.0925 mL 0.4623 mL 0.9246 mL 2.3114 mL
60 mM 0.0770 mL 0.3852 mL 0.7705 mL 1.9262 mL
80 mM 0.0578 mL 0.2889 mL 0.5778 mL 1.4446 mL
100 mM 0.0462 mL 0.2311 mL 0.4623 mL 1.1557 mL
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NH2-C6-NH-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-C6-NH-Boc51857-17-1PROTAC LinkersPROTAClinkerMcl-1Inhibitorinhibitorinhibit

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