2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NIC-12

NIC-12 is a potent NLRP3 inhibitor. NIC-12 selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model. NIC-12 inhibits NLRP3 inflammasome activation in mouse macrophages.

For research use only. We do not sell to patients.

NIC-12 Chemical Structure

NIC-12 Chemical Structure

CAS No. : 2409826-23-7

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NIC-12 Related Antibodies

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Description

NIC-12 is a potent NLRP3 inhibitor. NIC-12 selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model. NIC-12 inhibits NLRP3 inflammasome activation in mouse macrophages[1].

Molecular Weight

462.01

Formula

C22H28ClN5O2S
CAS No.
SMILES

CC(C1=NN(C(C2=CC3=C(N21)C=C(S3)Cl)=O)CC(N[C@@H]4CCCN(C4)CC5CC5)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NIC-12 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NIC-122409826-23-7NIC12NIC 12NOD-like Receptor (NLR)NLRP3NIC-11CRID3Inhibitorinhibitorinhibit

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