2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. NO-711

NO-711 (NNC-711) free acid is a novel potent and selective inhibitor of γ-aminobutyric acid uptake. NO-711 inhibits synaptosomal (IC50 = 47 nM), neuronal (IC50 = 1238 nM) and glial (IC50 = 636 nM) GABA uptake in vitro.

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NO-711 Chemical Structure

NO-711 Chemical Structure

CAS No. : 159094-94-7

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NO-711 Related Antibodies

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Description

NO-711 (NNC-711) free acid is a novel potent and selective inhibitor of γ-aminobutyric acid uptake. NO-711 inhibits synaptosomal (IC50 = 47 nM), neuronal (IC50 = 1238 nM) and glial (IC50 = 636 nM) GABA uptake in vitro[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
> 1000 μM
Compound: 22
Inhibition of mouse BGT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
Inhibition of mouse BGT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
[PMID: 26706177]
HEK293 IC50
> 1000 μM
Compound: 22
Inhibition of mouse GAT2 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
Inhibition of mouse GAT2 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
[PMID: 26706177]
HEK293 IC50
> 1000 μM
Compound: 22
Inhibition of mouse GAT3 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
Inhibition of mouse GAT3 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
[PMID: 26706177]
HEK293 IC50
≤ 0.53 μM
Compound: 6, NO711
Binding affinity to mouse GAT1 expressed in HEK293 cells membranes using LC-ESI-MS/MS analysis by [2H10]NO711 binding inhibition assay
Binding affinity to mouse GAT1 expressed in HEK293 cells membranes using LC-ESI-MS/MS analysis by [2H10]NO711 binding inhibition assay
[PMID: 23336362]
HEK293 IC50
0.04 μM
Compound: 6, NO711
Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysis
Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysis
[PMID: 23336362]
HEK293 IC50
0.18 μM
Compound: 22
Inhibition of mouse GAT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
Inhibition of mouse GAT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
[PMID: 26706177]
Molecular Weight

350.41

Formula

C21H22N2O3
CAS No.
SMILES

O=C(C1=CCCN(CCO/N=C(C2=CC=CC=C2)\C3=CC=CC=C3)C1)O
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Purity & Documentation
References
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NO-711 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NO-711159094-94-7NNC-711NO711NO 711NNC711NNC 711GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorγ-aminobutyric acidsynaptosomalneuronal;Inhibitorinhibitorinhibit

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