NOS1-IN-1

Cat. No.: HY-130452 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a K_i of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (K_i=39 μM) and iNOS (K_i=325 μM) , respectively. NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP).

For research use only. We do not sell to patients.

NOS1-IN-1 Chemical Structure

CAS No. : 357965-99-2

Size	Price	Stock	Quantity
500 μg	USD 80	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All NO Synthase Isoform Specific Products:

View All Isoforms

nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
Customer Review

Description

NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a K_i of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (K_i=39 μM) and iNOS (K_i=325 μM) , respectively^[1]. NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP)^[2].

IC₅₀ & Target

nNOS

120 nM (Ki)

Molecular Weight

589.37

Formula

C₁₄H₂₄F₉N₇O₈

CAS No.

357965-99-2

Appearance

Solid

Color

White to off-white

SMILES

N=C(N[N+]([O-])=O)NCCC[C@H](N)CNCCN.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (84.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6967 mL	8.4836 mL	16.9673 mL
5 mM	0.3393 mL	1.6967 mL	3.3935 mL
10 mM	0.1697 mL	0.8484 mL	1.6967 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (250 KB) HNMR (179 KB) RP-HPLC (85 KB) LCMS (309 KB)

Handling Instructions (2659 KB)

References

[1]. J M Hah, et al. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem. 2001 Aug 2;44(16):2667-70. [Content Brief]

[2]. Haitao Ji, et al. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann Neurol. 2009 Feb;65(2):209-17. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.6967 mL	8.4836 mL	16.9673 mL	42.4182 mL
	5 mM	0.3393 mL	1.6967 mL	3.3935 mL	8.4836 mL
	10 mM	0.1697 mL	0.8484 mL	1.6967 mL	4.2418 mL
	15 mM	0.1131 mL	0.5656 mL	1.1312 mL	2.8279 mL
	20 mM	0.0848 mL	0.4242 mL	0.8484 mL	2.1209 mL
	25 mM	0.0679 mL	0.3393 mL	0.6787 mL	1.6967 mL
	30 mM	0.0566 mL	0.2828 mL	0.5656 mL	1.4139 mL
	40 mM	0.0424 mL	0.2121 mL	0.4242 mL	1.0605 mL
	50 mM	0.0339 mL	0.1697 mL	0.3393 mL	0.8484 mL
	60 mM	0.0283 mL	0.1414 mL	0.2828 mL	0.7070 mL
	80 mM	0.0212 mL	0.1060 mL	0.2121 mL	0.5302 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

NOS1-IN-1 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOS1-IN-1357965-99-2NO SynthaseNitric oxide synthasesNOSNeurological disease,?cerebral palsyCPneuronalInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks