NR160 

NR160 is a selective HDAC6 inhibitor with an IC₅₀ value of 30 nM. NR160 shows low cytotoxicity against leukemia cell line. NR160 augments the apoptosis induction of Bortezomib (HY-10227) (proteasome inhibitor), Epirubicin (HY-13624) and Daunorubicin (HY-13062A) significantly^[1][2].

NR160 (compound 6I) (2.5 μM and 5 μM; 24 h) induces α-tubulin acetylation (ac-α-tubulin)^[1].
NR160 (1-50 μM; 24 h) shows low cytotoxicity against leukemia cell lines with IC50s >20 μM^[1].
NR160 (2.5 μM, 5 μM; 24 h) enhances the cytotoxicity induction of Bortezomib, Epirubicin and Daunorubicin in HL60 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

510.47

C₂₅H₂₁F₃N₆O₃

2484895-50-1

O=C(N(CC1=CC=C(C(NO)=O)C=C1)CC2=NN=NN2CC3=CC=CC=C3)C4=CC=CC=C4C(F)(F)F

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Reßing N, et al. Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups. J Med Chem. 2020 Sep 24;63(18):10339-10351.  [Content Brief]

  [2]. Najib N N, et al. Correlation between the acoustic and dynamic mechanical properties of natural rubber foam: Effect of foaming temperature[J]. Materials & Design, 2011, 32(2): 505-511.