2. Metabolic Enzyme/Protease
  3. FXR
  4. NR1H4 activator 1

NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease.

For research use only. We do not sell to patients.

NR1H4 activator 1 Chemical Structure

NR1H4 activator 1 Chemical Structure

CAS No. : 2242855-68-9

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NR1H4 activator 1 Related Antibodies

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Description

NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease[1].

IC50 & Target

EC50: 1 nM (Famesoid X Receptor)[1]
In Vitro

NR1H4 activator 1 exhibits a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. This assay is aim to determinate the ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NR1H4 activator 1 Related Antibodies
Molecular Weight

619.85

Formula

C34H53NO7S
CAS No.
SMILES

C[C@@]12[C@@H]([C@H](C)COC(NS(=O)(C3=CC=C(OC(C)C)C=C3)=O)=O)CC[C@@]1([H])[C@]4([H])[C@H](O)[C@H](CC)[C@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NR1H4 activator 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NR1H4 activator 12242855-68-9FXRNR1H4activatoragonistgastrointestinaldiseaseInhibitorinhibitorinhibit

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