1. Membrane Transporter/Ion Channel
  2. Chloride Channel
  3. NS3736

NS3736 is an orally effective chloride channel inhibitor that can be used for the research of osteoporosis. NS3736 targets the CIC-7 channel in osteocytes, blocks osteoclast acidification and resorption in vitro, with IC50=30 μM. In a rat model of ovariectomy-induced osteoporosis, NS3736 can enhance bone strength and bone density.

For research use only. We do not sell to patients.

NS3736 Chemical Structure

NS3736 Chemical Structure

CAS No. : 265646-94-4

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Description

NS3736 is an orally effective chloride channel inhibitor that can be used for the research of osteoporosis. NS3736 targets the CIC-7 channel in osteocytes, blocks osteoclast acidification and resorption in vitro, with IC50=30 μM. In a rat model of ovariectomy-induced osteoporosis, NS3736 can enhance bone strength and bone density[1].

IC50 & Target

CIC-7[1]

Molecular Weight

461.62

Formula

C15H9BrClF3N6O

CAS No.
SMILES

O=C(NC1=C(C2=NN=NN2)C=C(Br)C=C1)NC3=CC=C(C(C(F)(F)F)=C3)Cl

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NS3736
Cat. No.:
HY-164532
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