2. Anti-infection Metabolic Enzyme/Protease
  3. HCV Protease
  4. NS5A-IN-4

NS5A-IN-4 (Compound 1.12) is an orally active pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with IC50 values of 1.2, 2296, 4.6, 362, 10.3 and 693 pM against gT1b, gT1a, gT2a, gT3a, gT4a and gT5a. NS5A-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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NS5A-IN-4 Chemical Structure

NS5A-IN-4 Chemical Structure

CAS No. : 2088243-03-0

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NS5A-IN-4 Related Antibodies

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Description

NS5A-IN-4 (Compound 1.12) is an orally active pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with IC50 values of 1.2, 2296, 4.6, 362, 10.3 and 693 pM against gT1b, gT1a, gT2a, gT3a, gT4a and gT5a[1]. NS5A-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

IC50: 1.2 pM (gT1b), 4.6 pM (gT2a), 10.3 pM (gT4a), 362 pM (gT3a), 693 pM (gT5a), 2296 pM (gT1a)[1]
Molecular Weight

820.93

Formula

C47H48N8O6
CAS No.
SMILES

COC(N[C@@H](C(C)C)C(N1[C@H](C2=NC=C(C3=CC(C4=CC=CC=C4)=C(C=C3)C#CC#CC5=CN=C([C@H]6N(CCC6)C([C@@H](C7=CC=CC=C7)NC(OC)=O)=O)N5)N2)CCC1)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NS5A-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NS5A-IN-42088243-03-0HCV ProteaseHCVHuh7Inhibitorinhibitorinhibit

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