NSC 288387

Cat. No.: HY-134309: FAQs
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NSC 288387 is a pan-flavivirus MTase inhibitor. NSC 288387 binds to the SAM-binding pocket. NSC 288387 inhibits ZIKV with an IC₅₀ of 0.2 μM. NSC 288387 also inhibits viral replication in cell culture.

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NSC 288387 Chemical Structure

CAS No. : 61369-43-5

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Description	NSC 288387 is a pan-flavivirus MTase inhibitor. NSC 288387 binds to the SAM-binding pocket. NSC 288387 inhibits ZIKV with an IC₅₀ of 0.2 μM. NSC 288387 also inhibits viral replication in cell culture^[1].
Molecular Weight	348.36
Formula	C₁₉H₁₆N₄O₃
CAS No.	61369-43-5
SMILES	O=C(N1C2=CC=CC=C2)N=C3N(CCOC)C4=CC=CC=C4N=C3C1=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Samrat SK, et al. Broad-Spectrum Small-Molecule Inhibitors Targeting the SAM-Binding Site of Flavivirus NS5 Methyltransferase. ACS Infect Dis. 2023 Jul 14;9(7):1319-1333. [Content Brief]

NSC 288387 Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 28838761369-43-5NSC288387NSC-288387Virus ProteaseZIKVantiviralMTaseSAM-binding pocketviral replicationDENV3Inhibitorinhibitorinhibit

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NSC 288387

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