NSC114792

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NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5.

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NSC114792 Chemical Structure

CAS No. : 17392-79-9

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References
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Description

NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5^[1].

IC₅₀ & Target^[1]

JAK3

In Vitro

NSC114792 (0, 5, 10, 20 µM; 24, 48, 72 h) inhibits BaF3-JAK3^V674A and BKO84 cell viability in a time and dose-dependent manner^[1].
NSC114792 (0, 5, 10, 20 µM) decreases the protein expression of p-JAK3 and p-STAT5 in a dose-dependent manner^[1].
NSC114792 (0, 5, 10, 20 µM; 72 h) induces apoptosis in a dose-dependent manner in L540 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	L540, HDLM-2, MDA-MB-468, DU145 cells
Concentration:	0, 5, 10, 20 µM
Incubation Time:	0, 24, 48, 72 h
Result:	Inhibited cell viability in a time and dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:	BKO84 cells
Concentration:	0, 5, 10, 20 µM
Incubation Time:
Result:	Decreased the protein expression of p-JAK3 and p-STAT5 in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:	L540 cells
Concentration:	0, 10, 20 µM
Incubation Time:	72 h
Result:	Induced apoptosis and increased the expression of cleaved PARP and cleaved Capase-3, decreased the protein expression of Bcl-2, Bcl-Xl, Mcl-1, Survivin in a dose-dependent manner.

Molecular Weight

464.62

Formula

C₂₆H₃₂N₄O₂S

CAS No.

17392-79-9

SMILES

C[C@@]12[C@@H](C(CN3C=NC4=C3N=CNC4=S)=O)CC[C@@]1([H])[C@]5([H])CCC6=CC(CC[C@]6(C)[C@@]5([H])CC2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kim BH, et al. NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. Mol Cancer. 2010 Feb 11;9:36. [Content Brief]

NSC114792 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC11479217392-79-9NSC 114792NSC-114792JAKApoptosisJanus kinaseBKO84 cellsL540 cellsapoptosisp-JAK3p-STAT5Inhibitorinhibitorinhibit

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