2. Apoptosis
  3. Apoptosis
  4. NSD2-IN-1

NSD2-IN-1 (compound 38) is a potent and high selective NSD2-PWWP1 (nuclear receptor-binding SET domain 2-PWWP1) inhibitor, with an IC50 of 0.11 μM. NSD2-IN-1 can bind to NSD2-PWWP1 and then affect the expression of genes regulated by NSD2. NSD2-IN-1 induces apoptosis and cell cycle arrest.

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NSD2-IN-1 Chemical Structure

NSD2-IN-1 Chemical Structure

CAS No. : 2797183-37-8

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NSD2-IN-1 Related Antibodies

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Description

NSD2-IN-1 (compound 38) is a potent and high selective NSD2-PWWP1 (nuclear receptor-binding SET domain 2-PWWP1) inhibitor, with an IC50 of 0.11 μM. NSD2-IN-1 can bind to NSD2-PWWP1 and then affect the expression of genes regulated by NSD2. NSD2-IN-1 induces apoptosis and cell cycle arrest[1].

IC50 & Target

IC50: 0.11 ± 0.01 μM (NSD2)[1]
Cellular Effect
Cell Line Type Value Description References
KMS-11 IC50
8.43 μM
Compound: 38
Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay
Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay
[PMID: 35704853]
MM1.S IC50
10.95 μM
Compound: 38
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay
[PMID: 35704853]
MV4-11 IC50
2.23 μM
Compound: 38
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay
[PMID: 35704853]
RS4-11 IC50
6.3 μM
Compound: 38
Antiproliferative activity against human RS4-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay
Antiproliferative activity against human RS4-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay
[PMID: 35704853]
In Vitro

NSD2-IN-1 inhibits cell proliferation in MV4:11, RS4:11, KMS11, and MM1S cells, with IC50 values of 2.23, 6.30, 8.43, and 10.95 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSD2-IN-1 Related Antibodies
Molecular Weight

449.59

Formula

C29H31N5
CAS No.
SMILES

CN1C=NC(C2=C(C=C(C=C2C)CN3CCC(CC3)N)C)=C1C4=CC=C(C5=C4C=CC=C5)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NSD2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSD2-IN-12797183-37-8Apoptosisnuclear receptor-binding SET domainNSD2PWWP1MV4:11RS4:11KMS11MM1SanticancerapoptosisInhibitorinhibitorinhibit

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