NVP-AEW541 dihydrochloride (Synonyms: AEW541 dihydrochloride)

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NVP-AEW541 dihydrochloride (AEW541 dihydrochloride) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC₅₀ value of 0.15 μM. NVP-AEW541 dihydrochloride also inhibits InsR, IC₅₀ with a value of 0.14 μM. NVP-AEW541 dihydrochloride has antitumor activity.

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NVP-AEW541 dihydrochloride Chemical Structure

CAS No. : 2320261-63-8

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Other In-stock Forms of NVP-AEW541 dihydrochloride:

NVP-AEW541

Other Forms of NVP-AEW541 dihydrochloride:

NVP-AEW541 In-stock

6 Publications Citing Use of MCE NVP-AEW541 dihydrochloride

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Description	NVP-AEW541 dihydrochloride (AEW541 dihydrochloride) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC₅₀ value of 0.15 μM. NVP-AEW541 dihydrochloride also inhibits InsR, IC₅₀ with a value of 0.14 μM. NVP-AEW541 dihydrochloride has antitumor activity^[1].
Molecular Weight	512.47
Formula	C₂₇H₃₁Cl₂N₅O
CAS No.	2320261-63-8
SMILES	[H]Cl.[H]Cl.NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCC4)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (276 KB) Handling Instructions (2659 KB)
References	[1]. García-Echeverría C, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5(3):231-9. [Content Brief]

NVP-AEW541 dihydrochloride Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NVP-AEW5412320261-63-8AEW541AEW 541AEW-541IGF-1RInsulin ReceptorAutophagyInsulin-like growth factor-1 receptorInhibitorNWT-21Antitumorinhibitorinhibit

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NVP-AEW541 dihydrochloride (Synonyms: AEW541 dihydrochloride)

Other Forms of NVP-AEW541 dihydrochloride:

NVP-AEW541 dihydrochloride Related Antibodies

6 Publications Citing Use of MCE NVP-AEW541 dihydrochloride

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review