OBHS

Cat. No.: HY-146424: FAQs
Data Sheet Handling Instructions

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OBHS is an estrogen receptor α (ERα) inhibitor. OBHS can also be used as a blowing agent.

For research use only. We do not sell to patients.

OBHS Chemical Structure

CAS No. : 870614-18-9

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

OBHS is an estrogen receptor α (ERα) inhibitor. OBHS can also be used as a blowing agent^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	> 100 μM Compound: OBHS	Antiproliferative activity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 25993269]
HEK-293T	IC₅₀	0.014 μM Compound: OBHS	Antagonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay Antagonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay	[PMID: 25993269]
HEK-293T	EC₅₀	0.095 μM Compound: OBHS	Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as stimulation of transcriptional activity after 24 hrs by luciferase reporter gene assay Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as stimulation of transcriptional activity after 24 hrs by luciferase reporter gene assay	[PMID: 25993269]
HEK-293T	IC₅₀	0.581 μM Compound: OBHS	Antagonist activity at ER-beta (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay Antagonist activity at ER-beta (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay	[PMID: 25993269]
MCF7	IC₅₀	20.9 μM Compound: OBHS	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 25993269]
Vero	IC₅₀	> 100 μM Compound: OBHS	Antiproliferative activity against african green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTT assay Antiproliferative activity against african green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 25993269]

Molecular Weight

436.48

Formula

C₂₄H₂₀O₆S

CAS No.

870614-18-9

SMILES

O=S([C@H]1C[C@@H]2C(C3=CC=C(C=C3)O)=C([C@H]1O2)C4=CC=C(C=C4)O)(OC5=CC=CC=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. He M, et al. Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer. Eur J Med Chem. 2020 Jun 1;195:112281. [Content Brief]

[2]. Srikham J, et al. Foamability of Natural rubber (NR)/Poly (butylenes adipate-co-terephthalate)(PBAT) Thermoplastic Vulcanizate with OBSH as a blowing agent. 2020 IOP Conf. Ser.: Mater. Sci. Eng. 965 012018.

OBHS Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OBHS870614-18-9Estrogen Receptor/ERRbreast cancerblowing agentInhibitorinhibitorinhibit

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