2. Cell Cycle/DNA Damage Epigenetics Autophagy
  3. PARP Autophagy Mitophagy
  4. Olaparib-d8

Olaparib-d8  (Synonyms: AZD2281-d8; KU0059436-d8)

Cat. No.: HY-10162S1 Purity: 99.57%
SDS COA Handling Instructions

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Olaparib-d8 is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

For research use only. We do not sell to patients.

Olaparib-d<sub>8</sub> Chemical Structure

Olaparib-d8 Chemical Structure

Size Price Stock Quantity
1 mg USD 340 In-stock
5 mg USD 850 In-stock
10 mg USD 1360 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Olaparib-d8:

Olaparib-d8 Related Antibodies

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View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

Olaparib-d8 is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

Molecular Weight

442.51

Formula

C24H15D8FN4O3
Unlabeled CAS

763113-22-0
Appearance

Solid

Color

White to off-white

SMILES

O=C1NN=C(CC2=CC=C(F)C(C(N3C([2H])([2H])C([2H])([2H])N(C(C4CC4)=O)C([2H])([2H])C3([2H])[2H])=O)=C2)C5=C1C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (225.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (225.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 50 mg/mL (112.99 mM; Need ultrasonic)

DMF : 50 mg/mL (112.99 mM; Need ultrasonic)

Ethanol : 3.12 mg/mL (7.05 mM; ultrasonic and warming and heat to 60°C)

Ethanol : 3.12 mg/mL (7.05 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2598 mL 11.2992 mL 22.5984 mL
5 mM 0.4520 mL 2.2598 mL 4.5197 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / Ethanol / DMF / DMF / DMSO / DMSO 1 mM 2.2598 mL 11.2992 mL 22.5984 mL 56.4959 mL
5 mM 0.4520 mL 2.2598 mL 4.5197 mL 11.2992 mL
DMF / DMF / DMSO / DMSO 10 mM 0.2260 mL 1.1299 mL 2.2598 mL 5.6496 mL
15 mM 0.1507 mL 0.7533 mL 1.5066 mL 3.7664 mL
20 mM 0.1130 mL 0.5650 mL 1.1299 mL 2.8248 mL
25 mM 0.0904 mL 0.4520 mL 0.9039 mL 2.2598 mL
30 mM 0.0753 mL 0.3766 mL 0.7533 mL 1.8832 mL
40 mM 0.0565 mL 0.2825 mL 0.5650 mL 1.4124 mL
50 mM 0.0452 mL 0.2260 mL 0.4520 mL 1.1299 mL
60 mM 0.0377 mL 0.1883 mL 0.3766 mL 0.9416 mL
80 mM 0.0282 mL 0.1412 mL 0.2825 mL 0.7062 mL
100 mM 0.0226 mL 0.1130 mL 0.2260 mL 0.5650 mL
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Olaparib-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olaparib-d8AZD2281-d8KU0059436-d8PARPAutophagyMitophagypoly ADP ribose polymerase Mitochondrial AutophagyInhibitorinhibitorinhibit

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