2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor
  3. Cannabinoid Receptor PPAR
  4. OLHHA

OLHHA is a dual CB1 receptor antagonist and PPARα agonist. OLHHA also is a alcohol intake inhibitor with an EC50 value of 0.2 mg/kg. OLHHA reduces both hepatic lipid accumulation and circulating triglyceride levels. OLHHA shows anti-steatotic activity and has the potential for the research of non-alcoholic fatty liver disease (NAFLD).

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OLHHA Chemical Structure

OLHHA Chemical Structure

CAS No. : 1258011-97-0

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Based on 1 publication(s) in Google Scholar

OLHHA Related Antibodies

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Description

OLHHA is a dual CB1 receptor antagonist and PPARα agonist. OLHHA also is a alcohol intake inhibitor with an EC50 value of 0.2 mg/kg. OLHHA reduces both hepatic lipid accumulation and circulating triglyceride levels. OLHHA shows anti-steatotic activity and has the potential for the research of non-alcoholic fatty liver disease (NAFLD)[1][2].

In Vivo

OLHHA (5 mg/kg; i.p.; daily for 15 days) reduces both hepatic lipid accumulation and circulating triglyceride levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 9-week-old male Zucker rats (genetic obesity)[2]
Dosage: 5 mg/kg
Administration: I.p.; daily for 15 days
Result: Reduced the liver fat content and plasma triglyceride levels, and this was accompanied by a general improvement in the profile of plasma parameters related to liver damage in the obese rats, significantly reduced the body weight gain and decreased in the relative expression of CB1 in lean rats.
Molecular Weight

431.65

Formula

C27H45NO3
CAS No.
SMILES

CCCCCCCC/C=C\CCCCCCCC(NC(C)CC1=CC=C(O)C(O)=C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OLHHA Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OLHHA1258011-97-0Cannabinoid ReceptorPPARPeroxisome proliferator-activated receptorshepatic lipidtriglycerideanti-steatoticNAFLDCB1Inhibitorinhibitorinhibit

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