Org37684

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Org37684 is a highly potent 5-HT_2C receptor agonist (pEC₅₀=8.17). Org37684 exhibits a rank order of potency of 5-HT_2C>5-HT_2B>5-HT_2A. Its selectivity for the 5-HT2C receptor is approximately 2.5 times over the 5-HT2B (pEC₅₀=7.96) and ten times for the 5-HT_2A (pEC₅₀=7.11) receptor.

For research use only. We do not sell to patients.

Org37684 Chemical Structure

CAS No. : 213007-95-5

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Description	Org37684 is a highly potent 5-HT_2C receptor agonist (pEC₅₀=8.17). Org37684 exhibits a rank order of potency of 5-HT_2C>5-HT_2B>5-HT_2A. Its selectivity for the 5-HT2C receptor is approximately 2.5 times over the 5-HT2B (pEC₅₀=7.96) and ten times for the 5-HT_2A (pEC₅₀=7.11) receptor^[1].
In Vitro	Org37684 is an agonist at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Org37684 Related Antibodies
Molecular Weight	269.77
Formula	C₁₄H₂₀ClNO₂
CAS No.	213007-95-5
SMILES	COC1=C(O[C@@H]2CNCC2)C3=C(CCC3)C=C1.[H]Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Porter RH, et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br J Pharmacol. 1999;128(1):13-20. [Content Brief]

Org37684 Related Classifications

Neurological Disease

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Org37684213007-95-5Org 37684Org-376845-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorCHO-K1cellssubtypeInhibitorinhibitorinhibit

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Org37684

Org37684 Related Antibodies

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