P-gp inhibitor 13 

P-gp inhibitor 13 is a P-gp inhibitor. P-gp inhibitor 13 can reverse P-glycoprotein-mediated paclitaxel resistance in A2780/T cell. P-gp inhibitor 13 can be used for the research of advanced acute myeloid leukemia^[1].

P-gp inhibitor 13 (Compound 27f) shows a remarkable chemo-sensitization in A2780/T cells with an IC₅₀ value of 0.010 μM^[1].
P-gp inhibitor 13 is effective to increase the accumulation of paclitaxel and Rhodamine 123 via inhibiting P-gp for reversing multidrug-resistance^[1].
P-gp inhibitor 13 hardly has relevant cardiac toxicity^[1].
P-gp inhibitor 13 (2.5 μM, 5 μM, 10 μM, 20 μM) demonstrates concentration-dependent MDR reversal activities in A2780/T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

546.61

C₃₂H₃₄O₈

3041121-57-4

COC1=CC(CC(OCC2=C3OC(C(CC4=CC=CC=C4)=C(C3=CC=C2OC(C)C)C)=O)=O)=CC(OC)=C1OC

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• [1]. Wang W, et al. Design, synthesis and biological evaluation of seco-DSP/DCK derivatives reversing P-glycoprotein-mediated paclitaxel resistance in A2780/T cells. Eur J Med Chem. 2023;250:115218.  [Content Brief]