2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. P-gp inhibitor 14

P-gp inhibitor 14 (Compound 8a) is a high affinity P-gp inhibitor. P-gp inhibitor 14 reverses P-gp-mediated multidrug resistance (EC50=48.74 nM). P-gp inhibitor 14 has a weak inhibitory effect on CYP3A4 activity.

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P-gp inhibitor 14 Chemical Structure

P-gp inhibitor 14 Chemical Structure

CAS No. : 2892571-47-8

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P-gp inhibitor 14 Related Antibodies

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Description

P-gp inhibitor 14 (Compound 8a) is a high affinity P-gp inhibitor. P-gp inhibitor 14 reverses P-gp-mediated multidrug resistance (EC50=48.74 nM). P-gp inhibitor 14 has a weak inhibitory effect on CYP3A4 activity[1].

Molecular Weight

638.71

Formula

C37H38N2O8
CAS No.
SMILES

COC1=CC2=C(CN(CC2)CCC3=CC=C(C=C3)N4CC5=CC(OC)=C6OCOC6=C5C7=C(C4)C=C(C8=C7OCO8)OC)C=C1OC
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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P-gp inhibitor 14 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp inhibitor 142892571-47-8P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Drug resistanceMDRK562 cellA02 cellInhibitorinhibitorinhibit

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