2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. P-gp inhibitor 15

P-gp inhibitor 15 (compound 7a) is a nonsubstrate inhibitor of P-glycoprotein (Pgp). P-gp inhibitor 15 inhibits Pgp-ATPase activity，and interfers Pgp-mediated Rhodamine123 efflux. P-gp inhibitor 15 also enhances the inhibitory efficacy of Paclitaxel (HY-B0015)，inhibits tumor progress in nude mice KBV xenograft tumors model.

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P-gp inhibitor 15 Chemical Structure

P-gp inhibitor 15 Chemical Structure

CAS No. : 2303508-09-8

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P-gp inhibitor 15 Related Antibodies

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Description

P-gp inhibitor 15 (compound 7a) is a nonsubstrate inhibitor of P-glycoprotein (Pgp). P-gp inhibitor 15 inhibits Pgp-ATPase activity，and interfers Pgp-mediated Rhodamine123 efflux. P-gp inhibitor 15 also enhances the inhibitory efficacy of Paclitaxel (HY-B0015)，inhibits tumor progress in nude mice KBV xenograft tumors model[1].

Molecular Weight

572.86

Formula

C35H60N2O4
CAS No.
SMILES

C[C@@]12[C@](C([C@H](CC1)NC([C@@H]3CCCN3)=O)(C)C)(CC[C@]4(C)[C@]2([H])C[C@@H](O)[C@@]5([H])[C@@]4(C)CC[C@@H]5[C@]6(C)CC[C@H](C(C)(C)O)O6)[H]
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P-gp inhibitor 15 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp inhibitor 152303508-09-8P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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