2. Autophagy Neuronal Signaling
  3. PINK1/Parkin Mitophagy
  4. PARL-IN-1 TFA

PARL-IN-1 TFA is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 TFA inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 TFA promotes PINK1/Parkin-dependent mitophagy.

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PARL-IN-1 TFA Chemical Structure

PARL-IN-1 TFA Chemical Structure

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PARL-IN-1 TFA Related Antibodies

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Description

PARL-IN-1 TFA is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 TFA inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 TFA promotes PINK1/Parkin-dependent mitophagy[1].

IC50 & Target

IC50: 28 nM (PARL)[1]
Molecular Weight

834.92

Formula

C41H57F3N6O9
Appearance

Solid

SMILES

O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(C(NCCCCC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)C.FC(F)(C(O)=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
References
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PARL-IN-1 TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARL-IN-1PINK1/ParkinMitophagyMitochondrial AutophagyPINK1ParkinmitophagymitochondriaHEK293T cellsInhibitorinhibitorinhibit

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