2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. PARP1-IN-20

PARP1-IN-20 (compound 19A10) is a potent inhibitor of PARP1, with the IC50 of 4.62 nM and has similar low PARP-Trapping effect compared with Veliparib (HY-10129), IC50 (MDA-MB-436) >100 μM.

For research use only. We do not sell to patients.

PARP1-IN-20 Chemical Structure

PARP1-IN-20 Chemical Structure

CAS No. : 2659357-95-4

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PARP1-IN-20 Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

PARP1-IN-20 (compound 19A10) is a potent inhibitor of PARP1, with the IC50 of 4.62 nM and has similar low PARP-Trapping effect compared with Veliparib (HY-10129), IC50 (MDA-MB-436) >100 μM[1].

IC50 & Target

PARP1

4.62 nM (IC50)

Molecular Weight

539.40

Formula

C23H19BrN6O3S
CAS No.
SMILES

O=C(N)C1=C2C(NC(C3=CC=C(C(N4CCN(C(C5=CSC(Br)=N5)=O)CC4)=O)C=C3)=N2)=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PARP1-IN-20 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP1-IN-202659357-95-4PARPpoly ADP ribose polymeraseVeliparibPROTACsInhibitorinhibitorinhibit

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