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  3. PARP7-IN-12

PARP7-IN-12 is a potent PARP7 Inhibitor with an IC50 value of 7.836 nM. PARP7-IN-12 can be used in research of cancer.

For research use only. We do not sell to patients.

PARP7-IN-12 Chemical Structure

PARP7-IN-12 Chemical Structure

CAS No. : 2819700-92-8

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Description

PARP7-IN-12 is a potent PARP7 Inhibitor with an IC50 value of 7.836 nM. PARP7-IN-12 can be used in research of cancer[1].

IC50 & Target[1]

PARP7

7.836 nM (IC50)

In Vitro

PARP7-IN-12 (compound 85A; 16-24 h) inhibits cell proliferative with an IC50 values of 20.722 nM in H1373 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PARP7-IN-12 (compound 85A; 3 and 100 mg/kg; i.v. and p.o.; Balb/c mice) has good pharmacokinetic property[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice[1]
Dosage: 3 and 100 mg/kg
Administration: Intravenous injection (3 mg/kg) and oral administration (10 mg/kg)
Result: 1.19
Administration i.v. (3 mg/kg) p.o. (100 mg/kg)
CL (mL/min/kg) 32
Vss (L/kg) 0.4
Cmax (ng/mL) 21733
AUClast (ng·h/mL) 26442
Oral BA (F%) 48
Molecular Weight

545.94

Formula

C23H27ClF3N5O5

CAS No.
SMILES

CC1=C2C(N3[C@@](CCO2)([H])CN(CC3)C(CCOC[C@H](C)OC4=C(C(NN=C4)=O)C(F)(F)F)=O)=NC=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PARP7-IN-12
Cat. No.:
HY-151609
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