PARP7-IN-12

Cat. No.: HY-151609: FAQs
Data Sheet Handling Instructions

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PARP7-IN-12 is a potent PARP7 Inhibitor with an IC₅₀ value of 7.836 nM. PARP7-IN-12 can be used in research of cancer.

For research use only. We do not sell to patients.

PARP7-IN-12 Chemical Structure

CAS No. : 2819700-92-8

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PARP7-IN-12 is a potent PARP7 Inhibitor with an IC₅₀ value of 7.836 nM. PARP7-IN-12 can be used in research of cancer^[1].

IC₅₀ & Target^[1]

PARP7

7.836 nM (IC₅₀)

In Vitro

PARP7-IN-12 (compound 85A; 16-24 h) inhibits cell proliferative with an IC₅₀ values of 20.722 nM in H1373 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PARP7-IN-12 (compound 85A; 3 and 100 mg/kg; i.v. and p.o.; Balb/c mice) has good pharmacokinetic property^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Balb/c mice^[1]

Dosage:

3 and 100 mg/kg

Administration:

Intravenous injection (3 mg/kg) and oral administration (10 mg/kg)

Result:

1.19

Administration	i.v. (3 mg/kg)	p.o. (100 mg/kg)
CL (mL/min/kg)	32
Vss (L/kg)	0.4
C_max (ng/mL)		21733
AUC_last (ng·h/mL)		26442
Oral BA (F%)		48

Molecular Weight

545.94

Formula

C₂₃H₂₇ClF₃N₅O₅

CAS No.

2819700-92-8

SMILES

CC1=C2C(N3[C@@](CCO2)([H])CN(CC3)C(CCOC[C@H](C)OC4=C(C(NN=C4)=O)C(F)(F)F)=O)=NC=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jun LH, et, al. Tricyclic derivatives useful as parp7 inhibitors. WO2022170974.

PARP7-IN-12 Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP7-IN-122819700-92-8PARPpoly ADP ribose polymerasecancercell proliferativetricyclic derivativeInhibitorinhibitorinhibit

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