2. Epigenetics
  3. Epigenetic Reader Domain
  4. PBRM1-BD2-IN-1

PBRM1-BD2-IN-1 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-1 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 0.7 μM and 0.2 μM, respectively. PBRM1-BD2-IN-1 can be used for the research of cancer.

For research use only. We do not sell to patients.

PBRM1-BD2-IN-1 Chemical Structure

PBRM1-BD2-IN-1 Chemical Structure

CAS No. : 1915012-21-3

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PBRM1-BD2-IN-1 Related Antibodies

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Description

PBRM1-BD2-IN-1 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-1 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 0.7 μM and 0.2 μM, respectively. PBRM1-BD2-IN-1 can be used for the research of cancer[1].

IC50 & Target

Kd: 0.7 μM (PBRM1-BD2), 0.35 μM (PBRM1-BD5), 8.1 μM (SMARCA2B), 5.0 μM (SMARCA4) [1].
IC50: 0.2 μM (PBRM1-BD2)[1].
In Vitro

PBRM1-BD2-IN-1 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line[1].
PBRM1-BD2-IN-1 has binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B amd SMARCA4 with Kd values of 0.7 μM, 0.35 μM, 8.1 μM and 5.0 μM, respectively[1].
PBRM1-BD2-IN-1 has inhibitory activity for PBRM1-BD2 with IC50 value of 0.2 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PBRM1-BD2-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: Human prostate cell lines LNCaP, PC3, and RWPE-1
Concentration: 0, 0.1, 1, and 10 μM
Incubation Time: 5 days
Result: Inhibited LNCaP growth at higher concentrations.
Molecular Weight

302.80

Formula

C17H19ClN2O
CAS No.
SMILES

O=C1N=C(/C(CC2)=C/C(CC)CC)N2C3=C1C(Cl)=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PBRM1-BD2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PBRM1-BD2-IN-11915012-21-3Epigenetic Reader Domainpolybromo-1 (PBRM1)bromodomainbinding affinityinhibitorycancerInhibitorinhibitorinhibit

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