2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1-IN-25

PD-1-IN-25 (compound 43) is a potent PD-1/PD-L1 interaction inhibitor with an IC50 value of 10.2 nM in the HTRF assay. PD-1-IN-25 can promote CD8+ T cell activation through inhibiting PD-1/PD-L1 cellular signaling. PD-1-IN-25 delays the tumor growth.

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PD-1-IN-25 Chemical Structure

PD-1-IN-25 Chemical Structure

CAS No. : 2413100-40-8

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PD-1-IN-25 Related Antibodies

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Description

PD-1-IN-25 (compound 43) is a potent PD-1/PD-L1 interaction inhibitor with an IC50 value of 10.2 nM in the HTRF assay. PD-1-IN-25 can promote CD8+ T cell activation through inhibiting PD-1/PD-L1 cellular signaling. PD-1-IN-25 delays the tumor growth[1].

Molecular Weight

725.13

Formula

C37H35ClF2N2O9
CAS No.
SMILES

CC1=C(C=CC=C1C(F)(F)OC2=CC(OCC3=CC(C#N)=CC=C3)=C(C=C2Cl)CN[C@H]4[C@H]([C@@H]([C@H](OC4O)CO)O)O)C5=CC=C(OCCO6)C6=C5
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Purity & Documentation
References
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PD-1-IN-25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1-IN-252413100-40-8PD-1/PD-L1PD-1/Programmed death-ligand 1CD8+T celltumor growthInhibitorinhibitorinhibit

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PD-1-IN-25
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HY-157055
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