2. GPCR/G Protein
  3. G protein-coupled Bile Acid Receptor 1
  4. PEN (human)

PEN (human), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PEN (human) Chemical Structure

PEN (human) Chemical Structure

CAS No. : 597578-70-6

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Based on 1 publication(s) in Google Scholar

PEN (human) Related Antibodies

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1 Publications Citing Use of MCE PEN (human)

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Description

PEN (human), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1].

In Vitro

Mouse PEN (mPEN) and rat PEN (rPEN) only differ by one residue at the N-terminal end, whereas human PEN (hPEN) is more divergent and has the sequence PEG instead of PEN[2].
PEN binds and activates a GPCR in the brain[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PEN (human) Related Antibodies
Molecular Weight

2215.46

Formula

C97H159N27O32
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

AADHDVGSELPPEGVLGALLRV
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 1.96 mg/mL (0.88 mM; ultrasonic and adjust pH to 3 with HCl)

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Purity & Documentation

Purity: 99.68%

SDS (252 KB)

COA (261 KB) RP-HPLC (218 KB)

Handling Instructions (2659 KB)
References
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PEN (human) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PEN (human)597578-70-6G protein-coupled Bile Acid Receptor 1G-protein coupled receptor 19GPCR19TGR5GPBAR1GPR83GPCRProSAASneuropeptideInhibitorinhibitorinhibit

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PEN (human)
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HY-P2278
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