PF-00956980

Cat. No.: HY-108342: FAQs
Data Sheet Handling Instructions

Molarity Calculator

PF-00956980 is a reversible pan-JAK inhibitor with IC₅₀ values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases.

For research use only. We do not sell to patients.

PF-00956980 Chemical Structure

CAS No. : 1262832-74-5

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JAK1 JAK2 JAK3 Tyk2 JAK

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

JAK1

2.2 μM (IC₅₀)

JAK2

23.1 μM (IC₅₀)

JAK3

59.9 μM (IC₅₀)

In Vivo

The pharmacokinetic parameters of PF-00956980(compound 2) in rat or dog

Spesies	Dose (mg/kg)	Cl (mL/min/Kg)	Clunbound (mL/min/Kg)	V_ss (L/Kg)	Terminal T_1/2 (h)	Oral Bioavailability
Rat i.v.	0.5	48	>48,000	0.8	2.1	-
Rat p.o.	1	-	-	-	-	<5%
Dog i.v.	0.1	18	>18,000	1.0	2.0	-

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

342.44

Formula

C₁₈H₂₆N₆O

CAS No.

1262832-74-5

SMILES

O=C(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@H](C)CC1)N4CCCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Peter Jones, et al. Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. J Med Chem. 2017 Jan 26;60(2):767-786. [Content Brief]

PF-00956980 Related Classifications

Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-009569801262832-74-5PF00956980PF 00956980JAKJanus kinaseJAK1JAK2JAK3lungskin inflammatoryInhibitorinhibitorinhibit

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