2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. PF-00956980

PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases.

For research use only. We do not sell to patients.

PF-00956980 Chemical Structure

PF-00956980 Chemical Structure

CAS No. : 1262832-74-5

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PF-00956980 Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

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Description

PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases[1].

IC50 & Target[1]

JAK1

2.2 μM (IC50)

JAK2

23.1 μM (IC50)

JAK3

59.9 μM (IC50)

In Vivo

The pharmacokinetic parameters of PF-00956980(compound 2) in rat or dog

Spesies Dose (mg/kg) Cl (mL/min/Kg) Clunbound (mL/min/Kg) Vss (L/Kg) Terminal T1/2 (h) Oral Bioavailability
Rat i.v. 0.5 48 >48,000 0.8 2.1 -
Rat p.o. 1 - - - - <5%
Dog i.v. 0.1 18 >18,000 1.0 2.0 -

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

342.44

Formula

C18H26N6O
CAS No.
SMILES

O=C(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@H](C)CC1)N4CCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-00956980 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-009569801262832-74-5PF00956980PF 00956980JAKJanus kinaseJAK1JAK2JAK3lungskin inflammatoryInhibitorinhibitorinhibit

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