PF-4479745 

PF-4479745 is a potent and selective 5-HT_2C receptor agonist (EC₅₀: 10 nM, k_i: 15 nM). PF-4479745 can be used in the research of cardiovascular disease like hypertension^[1].

PF-4479745 (copmpound 17) exhibits metabolic stability in both human liver microsomes (HLM) and human hepatocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-4479745 (compound 17, intravenous injection) shows high clearance rate (104 mL/min/kg)^[1].
PF-4479745 demonstrates a robust dose-dependent effect in canine PUP (peak urethral pressure) model of SUI (stress urinary incontinence)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

282.38

C₁₇H₂₂N₄

1065110-43-1

CNC1=C2C([C@H](CNCC2)C)=NC(CC3=CC=CC=C3)=N1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. R Ian Storer, et al. Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors. J Med Chem. 2014  [Content Brief]