2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. PF-4522654

PF-4522654 is a potent, selective and brain-permeable 5-HT2C receptor agonist with an EC50 of 16 nM and a Ki of 8 nM. PF-4522654 shows no measurable functional agonism at no 5-HT2A and 5-HT2B receptors. PF-4522654 can be used for the study of stress urinary incontinence (SUI).

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PF-4522654 Chemical Structure

PF-4522654 Chemical Structure

CAS No. : 1065109-28-5

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PF-4522654 Related Antibodies

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Description

PF-4522654 is a potent, selective and brain-permeable 5-HT2C receptor agonist with an EC50 of 16 nM and a Ki of 8 nM. PF-4522654 shows no measurable functional agonism at no 5-HT2A and 5-HT2B receptors. PF-4522654 can be used for the study of stress urinary incontinence (SUI)[1].

IC50 & Target[1]

5-HT2C Receptor

16 nM (EC50)

5-HT2C Receptor

8 nM (Ki)

5-HT2B Receptor

>10000 nM (EC50)

Molecular Weight

304.34

Formula

C16H18F2N4
CAS No.
SMILES

FC(C1=NC(CCNCC2)=C2C(NC)=N1)(C3=CC=CC=C3)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-4522654 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-45226541065109-28-5PF4522654PF 45226545-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT2C receptor agonistbrain-permeablestress urinary incontinenceInhibitorinhibitorinhibit

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