Ph-HTBA

Cat. No.: HY-151797: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a K_d value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders.

For research use only. We do not sell to patients.

Ph-HTBA Chemical Structure

CAS No. : 2368927-41-5

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All CaMK Isoform Specific Products:

View All Isoforms

CaMK III CaMK II

Biological Activity
Purity & Documentation
References
Customer Review

Description	Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a K_d value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders^[1].
IC₅₀ & Target	Kd: 757 nM (CaMKIIα)^[1]
In Vitro	Ph-HTBA can inhibit HOCPCA binding with a K_i value of 1.4 μM^[1]. Ph-HTBA has binding affinity for CaMKIIα with a K_d value of 757 nM^[1]. Ph-HTBA (compound 1i) has a marked hub thermal stabilization effect along with a distinct CaMKIIα Trp403 flip upon binding^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Ph-HTBA Related Antibodies
In Vivo	Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	294.34
Formula	C₁₉H₁₈O₃
CAS No.	2368927-41-5
SMILES	O=C(O)/C=C1CCCC2=CC(C3=CC=CC=C3)=CC=C2C\1O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Yongsong Tian,et al. Exploring the NCS-382 Scaffold for CaMKIIα Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKIIα Hub Domain. J Med Chem. 2022 Nov 8. [Content Brief]

Ph-HTBA Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ph-HTBA2368927-41-5CaMKCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesaffinitybrain-penetratingmodulatorCaMKIIαAlzheimerParkinson diseaseneurodegenerative disorderischemiaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #