2. Neuronal Signaling
  3. CaMK
  4. Ph-HTBA

Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders.

For research use only. We do not sell to patients.

Ph-HTBA Chemical Structure

Ph-HTBA Chemical Structure

CAS No. : 2368927-41-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Ph-HTBA Related Antibodies

Top Publications Citing Use of Products

View All CaMK Isoform Specific Products:

View All Isoforms
CaMK III CaMK II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders[1].

IC50 & Target

Kd: 757 nM (CaMKIIα)[1]
In Vitro

Ph-HTBA can inhibit HOCPCA binding with a Ki value of 1.4 μM[1].
Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM[1].
Ph-HTBA (compound 1i) has a marked hub thermal stabilization effect along with a distinct CaMKIIα Trp403 flip upon binding[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ph-HTBA Related Antibodies
In Vivo

Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

294.34

Formula

C19H18O3
CAS No.
SMILES

O=C(O)/C=C1CCCC2=CC(C3=CC=CC=C3)=CC=C2C\1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Ph-HTBA Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ph-HTBA2368927-41-5CaMKCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesaffinitybrain-penetratingmodulatorCaMKIIαAlzheimerParkinson diseaseneurodegenerative disorderischemiaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Ph-HTBA
Cat. No.:
HY-151797
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.