PhAc-ALGP-Dox

Cat. No.: HY-P10760: FAQs
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PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC₅₀ values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells.

For research use only. We do not sell to patients.

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PhAc-ALGP-Dox Chemical Structure

CAS No. : 1616592-31-4

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Description	PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC₅₀ values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells^[1].
In Vitro	PhAc-ALGP-Dox is sequentially activated via a tumor-specific two-step cleavage, initiated by extracellular THOP1 and further processed by FAPα/DPP4^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. PhAc-ALGP-Dox Related Antibodies
Molecular Weight	1003.94
Formula	C₄₅H₅₈N₅O₁₉P
CAS No.	1616592-31-4
Sequence	{Phosphonoacetyl}-Ala-Leu-Gly-Pro-{Dox}
Sequence Shortening	{Phosphonoacetyl}-ALGP-{Dox}
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (258 KB) Handling Instructions (2659 KB)
References	[1]. Andrea Casazza, et al. PhAc-ALGP-Dox, a Novel Anticancer Prodrug with Targeted Activation and Improved Therapeutic Index. Mol Cancer Ther. 2022 Apr 1;21(4):568-581. [Content Brief]

PhAc-ALGP-Dox Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PhAc-ALGP-Dox1616592-31-4Antibody-Drug Conjugates (ADCs)Antibody-Drug ConjugatesdoxorubicinDoxFAPαDPP4metastaticTNBCMDA-MB-468MDA-MB-231Inhibitorinhibitorinhibit

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PhAc-ALGP-Dox

PhAc-ALGP-Dox Related Antibodies

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