2. Neuronal Signaling Autophagy
  3. Amyloid-β Autophagy
  4. PHF6 TFA

PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein.

For research use only. We do not sell to patients.

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PHF6 TFA Chemical Structure

PHF6 TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of PHF6 TFA:

PHF6 TFA Related Antibodies

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Description

PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein[1].

In Vitro

Aggregated tau-PHF6 (VQIVYK) TFA potentiates NLRP3 inflammasome expression and autophagy in human microglial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PHF6 TFA Related Antibodies
Molecular Weight

748.91 (free base)

Formula

C36H60N8O9.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Val-Gln-Ile-Val-Tyr-Lys
Sequence Shortening

VQIVYK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL

*"≥" means soluble, but saturation unknown.

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
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PHF6 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHF6PHF 6PHF-6Amyloid-βAutophagyβ-amyloid peptideAβAbetaMAPTMicrotubule associated protein tauNFT,Inhibitorinhibitorinhibit

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HY-P4808A
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