Phosphoglycolohydroxamic acid

Name: Phosphoglycolohydroxamic acid
Brand: MedChemExpress
SKU: HY-148077
Rating: 4.5 (1 reviews)

Cat. No.: HY-148077 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Phosphoglycolohydroxamic acid is a potent aldolase and triose-phosphate isomerase inhibitor. Phosphoglycolohydroxamic acid can be used in the research of antibacterial and antifungal area.

For research use only. We do not sell to patients.

Phosphoglycolohydroxamic acid Chemical Structure

CAS No. : 51528-59-7

Size	Price	Stock	Quantity
1 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1700	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2680	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Phosphoglycolohydroxamic acid is a potent aldolase and triose-phosphate isomerase inhibitor. Phosphoglycolohydroxamic acid can be used in the research of antibacterial and antifungal area^[1]^[2].

IC₅₀ & Target

Aldolase, triose-phosphate isomerase^[1]

In Vitro

Phosphoglycolohydroxamic acid competitively inhibits rabbit muscle FDP-aldolase and chicken triosephosphate isomerase over a wide range pH^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

171.05

Formula

C₂H₆NO₆P

CAS No.

51528-59-7

Appearance

Oil

Color

Colorless to off-white

SMILES

O=C(NO)COP(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (292.31 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8462 mL	29.2312 mL	58.4624 mL
5 mM	1.1692 mL	5.8462 mL	11.6925 mL
10 mM	0.5846 mL	2.9231 mL	5.8462 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (245 KB) HNMR (227 KB) CNMR (272 KB) LCMS (247 KB)

Handling Instructions (2659 KB)

References

[1]. By DENNIS J. LEWI, et al. Phosphoglycollohydroxamic Acid : an Inhibitor of Class I and I1 Aldolasesand Triosephosphate Isomerase. A Potential Antibacterial and Antifungal Agent. J. Chem. Soc., Chem. Commun., 1973, 713-715.

[2]. Sabine Gavalda, et al. N-Sulfonyl hydroxamate derivatives as inhibitors of class II fructose-1,6-diphosphate aldolase. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5375-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.8462 mL	29.2312 mL	58.4624 mL	146.1561 mL
	5 mM	1.1692 mL	5.8462 mL	11.6925 mL	29.2312 mL
	10 mM	0.5846 mL	2.9231 mL	5.8462 mL	14.6156 mL
	15 mM	0.3897 mL	1.9487 mL	3.8975 mL	9.7437 mL
	20 mM	0.2923 mL	1.4616 mL	2.9231 mL	7.3078 mL
	25 mM	0.2338 mL	1.1692 mL	2.3385 mL	5.8462 mL
	30 mM	0.1949 mL	0.9744 mL	1.9487 mL	4.8719 mL
	40 mM	0.1462 mL	0.7308 mL	1.4616 mL	3.6539 mL
	50 mM	0.1169 mL	0.5846 mL	1.1692 mL	2.9231 mL
	60 mM	0.0974 mL	0.4872 mL	0.9744 mL	2.4359 mL
	80 mM	0.0731 mL	0.3654 mL	0.7308 mL	1.8270 mL
	100 mM	0.0585 mL	0.2923 mL	0.5846 mL	1.4616 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.