PKC/PKD-IN-1

Cat. No.: HY-128142 Purity: 98.35%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D (PKC/PKD) inhibitor with an IC₅₀ value of 0.6 nM for PKD1. PKC/PKD-IN-1 can attenuate high-salt diet-induced cardiac hypertrophy and can be used in the study of heart failure.

For research use only. We do not sell to patients.

PKC/PKD-IN-1 Chemical Structure

CAS No. : 1071135-06-2

Size	Price	Stock	Quantity
1 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 835	Get quote	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

PKD1

0.6 nM (IC₅₀)

In Vivo

PKC/PKD-IN-1 (Compound 13C) (5-50 mg/kg; p.o.; once daily for 14 days) , in Dahl salt-sensitive (DSS) rats, can attenuate high-salt diet-induced cardiac hypertrophy at a dose of 50 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

388.51

Formula

C₂₃H₂₈N₆

CAS No.

1071135-06-2

Appearance

Solid

Color

White to off-white

SMILES

C1(NC2CCCCC2)=NC=CC(C3=CC4=C(C(N5CCNCC5)=N3)C=CN=C4)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 98.35%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (249 KB) HNMR (358 KB) RP-HPLC (155 KB)

Handling Instructions (2659 KB)

References

[1]. Meredith EL, et al. Identification of orally available naphthyridine protein kinase D inhibitors. J Med Chem. 2010;53(15):5400-5421. [Content Brief]

PKC/PKD-IN-1 Related Classifications

Cardiovascular Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKC/PKD-IN-11071135-06-2PKDPKCProtein kinase DProtein kinase CDahl salt-sensitive (DSS) ratscardiac hypertrophyheart failureInhibitorinhibitorinhibit

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