(+)-Epipinoresinol

Cat. No.: HY-N7534 Purity: 98.12%: FAQs
Data Sheet SDS COA Handling Instructions

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(+)-Epipinoresinol is a lignan compound. CYP81Q3 specifically catalyzes methylenedioxy bridge (MDB) formation in (+)-Epipinoresinol to produce (+)-Pluviatilol.

For research use only. We do not sell to patients.

(+)-Epipinoresinol Chemical Structure

CAS No. : 24404-50-0

Size	Price	Stock
1 mg	USD 400	Ask For Quote & Lead Time
5 mg	USD 1000	Ask For Quote & Lead Time

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Biological Activity
Purity & Documentation
References
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Description

(+)-Epipinoresinol is a lignan compound. CYP81Q3 specifically catalyzes methylenedioxy bridge (MDB) formation in (+)-Epipinoresinol to produce (+)-Pluviatilol^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	> 60 μM Compound: 3	Transactivation of GAL4-fused PPARalpha LBD expressed in HepG2 cells after 20 hrs by luminescence assay Transactivation of GAL4-fused PPARalpha LBD expressed in HepG2 cells after 20 hrs by luminescence assay	[PMID: 22381047]
HepG2	EC₅₀	10.3 μM Compound: 3	Transactivation of PPAR expressed in HepG2 cells after 20 hrs by luminescence assay Transactivation of PPAR expressed in HepG2 cells after 20 hrs by luminescence assay	[PMID: 22381047]
HepG2	EC₅₀	49.5 μM Compound: 3	Transactivation of GAL4-fused PPARbeta LBD expressed in HepG2 cells after 20 hrs by luminescence assay Transactivation of GAL4-fused PPARbeta LBD expressed in HepG2 cells after 20 hrs by luminescence assay	[PMID: 22381047]
HepG2	EC₅₀	58.6 μM Compound: 3	Transactivation of GAL4-fused PPARgamma LBD expressed in HepG2 cells after 20 hrs by luminescence assay Transactivation of GAL4-fused PPARgamma LBD expressed in HepG2 cells after 20 hrs by luminescence assay	[PMID: 22381047]
Neutrophil	IC₅₀	> 10 μg/mL Compound: 18	Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate	[PMID: 28218000]
Neutrophil	IC₅₀	3.4 μg/mL Compound: 18	Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins	[PMID: 28218000]
RAW264.7	IC₅₀	> 50 μM Compound: 15	Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA	[PMID: 24963714]
RAW264.7	IC₅₀	39.5 μM Compound: 15	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay	[PMID: 24963714]

Molecular Weight

358.39

Formula

C₂₀H₂₂O₆

CAS No.

24404-50-0

Appearance

Solid

Color

White to off-white

SMILES

COC(C=C(C=C1)[C@@]2([H])[C@]3([H])[C@@](CO2)([H])[C@](C(C=C4)=CC(OC)=C4O)([H])OC3)=C1O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 98.12%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (255 KB) HNMR (266 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Eiichiro Ono, et al. Formation of a Methylenedioxy Bridge in (+)-Epipinoresinol by CYP81Q3 Corroborates with Diastereomeric Specialization in Sesame Lignans. Plant Cell Physiol. 2018 Nov 1;59(11):2278-2287. [Content Brief]

(+)-Epipinoresinol Related Classifications

Others

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Epipinoresinol24404-50-0OthersInhibitorinhibitorinhibit

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