2. Metabolic Enzyme/Protease
  3. TrxR
  4. PMX464

PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells.

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PMX464 Chemical Structure

PMX464 Chemical Structure

CAS No. : 485842-97-5

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PMX464 Related Antibodies

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Description

PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.5 μM
Compound: 1
Growth inhibition of human A549 cells after 72 hrs by MTT assay
Growth inhibition of human A549 cells after 72 hrs by MTT assay
[PMID: 17343370]
HCT-116 IC50
0.03 μM
Compound: 1
Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
[PMID: 17343370]
HCT-116 GI50
0.11 μM
Compound: PMX 464
Antitumor activity against human HCT116 cells by MTT assay
Antitumor activity against human HCT116 cells by MTT assay
[PMID: 16908135]
HT-29 GI50
0.59 μM
Compound: PMX 464
Antitumor activity against human HT29 cells by MTT assay
Antitumor activity against human HT29 cells by MTT assay
[PMID: 16908135]
MCF7 GI50
0.44 μM
Compound: PMX 464
Antitumor activity against human MCF7 cells by MTT assay
Antitumor activity against human MCF7 cells by MTT assay
[PMID: 16908135]
MDA-MB-468 GI50
0.41 μM
Compound: PMX 464
Antitumor activity against human MDA-MB-468 cells by MTT assay
Antitumor activity against human MDA-MB-468 cells by MTT assay
[PMID: 16908135]
MRC5 EC50
0.18 μM
Compound: 4, PMX 464
Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay
Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay
[PMID: 22264753]
Molecular Weight

243.28

Formula

C13H9NO2S
CAS No.
SMILES

O=C1C=CC(O)(C2=NC3=CC=CC=C3S2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PMX464 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PMX464485842-97-5AW 464PMX 464PMX-464AW464AW-464TrxRThioredoxin Reductasethioredoxin-thioredoxin reductaseTrx/TrxRNF-κBInhibitorinhibitorinhibit

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