2. Anti-infection
  3. Reverse Transcriptase
  4. PNR-7-02

PNR-7-02 inhibits Pol η function with an IC50 value of near 8 μM, which binds to the little finger domain. PNR-7-02 is also an inhibitor against hRev1 and hpol lambda (λ). PNR-7-02 acts synergistically with Cisplatin (HY-17394) to kill chronic myeloid leukaemia and ovarian cancer cell lines. PNR-7-02 is an indole thio-barbituric acid (ITBA) derivative with both N-napthoyl moiety and 5-chloro substituent on the indole ring.

For research use only. We do not sell to patients.

PNR-7-02 Chemical Structure

PNR-7-02 Chemical Structure

CAS No. : 1633660-76-0

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PNR-7-02 Related Antibodies

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Description

PNR-7-02 inhibits Pol η function with an IC50 value of near 8 μM, which binds to the little finger domain. PNR-7-02 is also an inhibitor against hRev1 and hpol lambda (λ). PNR-7-02 acts synergistically with Cisplatin (HY-17394) to kill chronic myeloid leukaemia and ovarian cancer cell lines. PNR-7-02 is an indole thio-barbituric acid (ITBA) derivative with both N-napthoyl moiety and 5-chloro substituent on the indole ring[1][2].

Molecular Weight

445.92

Formula

C24H16ClN3O2S
CAS No.
SMILES

O=C1NC(NC(/C1=C\C2=CN(CC3=CC4=C(C=CC=C4)C=C3)C5=C2C=C(Cl)C=C5)=O)=S
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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PNR-7-02 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNR-7-021633660-76-0Reverse TranscriptasePol ηhRev1hpol lambda (λ)chronic myeloid leukaemiaovarian cancer cell linesITBA derivativeInhibitorinhibitorinhibit

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