2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. PPARα/δ agonist 1

PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist (PPARα EC50=7.0 nM; PPARδ EC50=8.4 nM). PPARα/δ agonist 1 is a high selectivity over PPARγ (PPARγ EC50=1316.1 nM). PPARα/δ agonist 1 has the potential for the research of nonalcoholic steatohepatitis.

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PPARα/δ agonist 1 Chemical Structure

PPARα/δ agonist 1 Chemical Structure

CAS No. : 2760128-48-9

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PPARα/δ agonist 1 Related Antibodies

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Description

PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist (PPARα EC50=7.0 nM; PPARδ EC50=8.4 nM). PPARα/δ agonist 1 is a high selectivity over PPARγ (PPARγ EC50=1316.1 nM). PPARα/δ agonist 1 has the potential for the research of nonalcoholic steatohepatitis[1].

IC50 & Target[1]

PPARα

7 nM (EC50)

PPARδ

8.4 nM (EC50)

PPARγ

1316.1 nM (EC50)

Molecular Weight

465.42

Formula

C22H22F3N3O5
CAS No.
SMILES

O=C1N(N=CN1C2=CC=C(C=C2)OC(F)(F)F)CC3=CC(C)=C(C(C)=C3)OC(C)(C(O)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PPARα/δ agonist 1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPARα/δ agonist 12760128-48-9PPARPeroxisome proliferator-activated receptorsPPARαPPARδNASHinflammatoryfibrotic diseasesnonalcoholic steatohepatitisInhibitorinhibitorinhibit

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