2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. PPARγ agonist 3

PPARγ agonist 3 (Compound 18a) is a potent and selective agonist of PPARγ. PPARγ agonist 3 is not cytotoxic neither on non-resistant nor on resistant cells. PPARγ agonist 3 exerts antitumor potency only in combination with Imatinib.

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PPARγ agonist 3 Chemical Structure

PPARγ agonist 3 Chemical Structure

CAS No. : 2011801-48-0

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PPARγ agonist 3 Related Antibodies

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Description

PPARγ agonist 3 (Compound 18a) is a potent and selective agonist of PPARγ. PPARγ agonist 3 is not cytotoxic neither on non-resistant nor on resistant cells. PPARγ agonist 3 exerts antitumor potency only in combination with Imatinib[1].

Cellular Effect
Cell Line Type Value Description References
COS-7 EC50
3.15 μM
Compound: 1-B
Transactivation at Gal4 fused PPARgamma LBD (unknown origin) expressed in African green monkey COS7 cells after 42 hrs by luciferase assay
Transactivation at Gal4 fused PPARgamma LBD (unknown origin) expressed in African green monkey COS7 cells after 42 hrs by luciferase assay
[PMID: 27569195]
Molecular Weight

369.46

Formula

C24H23N3O
CAS No.
SMILES

CCCC1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C(N)=O
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References
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PPARγ agonist 3 Related Classifications

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Keywords:

PPARγ agonist 32011801-48-0PPARγ agonist3PPARγ agonist-3PPARPeroxisome proliferator-activated receptorsPPARγcytotoxicnon-resistantantitumorimatinibInhibitorinhibitorinhibit

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