2. Immunology/Inflammation Apoptosis NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species MDM-2/p53
  4. PRDX1-IN-3

PRDX1-IN-3 (compound 19-048) is a PRDX1 covalent inhibitor with anti-colorectal cancer activity. PRDX1-IN-3 can effectively inhibit the proliferation of colorectal cancer cells, and its antitumor effect on nude mice with colorectal cancer carrying PRDX1 gene knockout is significantly reduced. PRDX1-IN-3 also upregulates the downstream genes of the p53 signaling pathway to exert an anticancer effect.

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PRDX1-IN-3 Chemical Structure

PRDX1-IN-3 Chemical Structure

CAS No. : 2566976-46-1

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PRDX1-IN-3 Related Antibodies

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Description

PRDX1-IN-3 (compound 19-048) is a PRDX1 covalent inhibitor with anti-colorectal cancer activity. PRDX1-IN-3 can effectively inhibit the proliferation of colorectal cancer cells, and its antitumor effect on nude mice with colorectal cancer carrying PRDX1 gene knockout is significantly reduced. PRDX1-IN-3 also upregulates the downstream genes of the p53 signaling pathway to exert an anticancer effect[1].

IC50 & Target

PRDX1[1]
Molecular Weight

550.73

Formula

C33H46N2O5
CAS No.
SMILES

C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)NC(N[C@@H](C)C(OC)=O)=O)C)(CC[C@@]4(C2=CC=C5C4=CC(C(O)=C5C)=O)C)C
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Purity & Documentation
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PRDX1-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRDX1-IN-32566976-46-1 Reactive Oxygen SpeciesMDM-2/p53Inhibitorinhibitorinhibit

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