Propantheline 

Propantheline is an orally active mAChR antagonist. Propantheline can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination^[1][2][3].

mAChR^[1]

Propantheline (10 μM-1 mM) decreases urinary bladder smooth muscle reactivity to Acetylcholine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propantheline (oral administration, 10-300 mg/kg) decreased the fecal pellet count and the incidences diarrhea in restraint stress-induced bowel dysfunction rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

368.49

C₂₃H₃₀NO₃⁺

298-50-0

CC([N+](C(C)C)(C)CCOC(C1C2=C(OC3=C1C=CC=C3)C=CC=C2)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. J Mokry, et al. Propantheline and in vitro reactivity of urinary bladder smooth muscle in guinea pigs. Bratisl Lek Listy. 2005;106(4-5):151-4.  [Content Brief]

  [2]. Richard Jewell, et al. Propantheline. xPharm: The Comprehensive Pharmacology Reference. 2007, Pages 1-5.

  [3]. S Kobayashi, et al. Effects of YM905, a novel muscarinic M3-receptor antagonist, on experimental models of bowel dysfunction in vivo. Jpn J Pharmacol. 2001 Jul;86(3):281-8.  [Content Brief]