2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Propantheline

Propantheline is an orally active mAChR antagonist. Propantheline can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination.

For research use only. We do not sell to patients.

Propantheline Chemical Structure

Propantheline Chemical Structure

CAS No. : 298-50-0

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Propantheline:

Propantheline Related Antibodies

Top Publications Citing Use of Products

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Propantheline is an orally active mAChR antagonist. Propantheline can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination[1][2][3].

IC50 & Target

mAChR[1]
In Vitro

Propantheline (10 μM-1 mM) decreases urinary bladder smooth muscle reactivity to Acetylcholine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propantheline Related Antibodies
In Vivo

Propantheline (oral administration, 10-300 mg/kg) decreased the fecal pellet count and the incidences diarrhea in restraint stress-induced bowel dysfunction rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Restraint stress-induced bowel dysfunction models in rats[3]
Dosage: 10-300 mg/kg
Administration: Oral administration
Result: Decreased the fecal pellet count with ED50 values of 41 mg/kg.
Dose-dependently decreased the incidences of diarrhea with ED50 values of 64 mg/kg.
Clinical Trial
Molecular Weight

368.49

Formula

C23H30NO3+
CAS No.
SMILES

CC([N+](C(C)C)(C)CCOC(C1C2=C(OC3=C1C=CC=C3)C=CC=C2)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Propantheline Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propantheline298-50-0mAChRMuscarinic acetylcholine receptorUrinationbladdercrampsIBSbowel dysfunctionInhibitorinhibitorinhibit

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