Propargyl-PEG2-OH

Name: Propargyl-PEG2-OH
Brand: MedChemExpress
SKU: HY-130541
Rating: 4.5 (1 reviews)

Cat. No.: HY-130541 Purity: 99.66%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Propargyl-PEG2-OH is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458). Propargyl-PEG2-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG2-OH Chemical Structure

CAS No. : 7218-43-1

Size	Price	Stock	Quantity
1 g	USD 34	In-stock	Estimated Time of Arrival: December 31
5 g	USD 104	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Propargyl-PEG2-OH is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)^[1]. Propargyl-PEG2-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

144.17

Formula

C₇H₁₂O₃

CAS No.

7218-43-1

Appearance

Liquid (Density: 1.06 g/cm³)

Color

Colorless to light yellow

SMILES

C#CCOCCOCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : ≥ 100 mg/mL (693.63 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.9363 mL	34.6813 mL	69.3626 mL
5 mM	1.3873 mL	6.9363 mL	13.8725 mL
10 mM	0.6936 mL	3.4681 mL	6.9363 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.66%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (241 KB) HNMR (116 KB) GC (204 KB)

Handling Instructions (2659 KB)

References

[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	6.9363 mL	34.6813 mL	69.3626 mL	173.4064 mL
	5 mM	1.3873 mL	6.9363 mL	13.8725 mL	34.6813 mL
	10 mM	0.6936 mL	3.4681 mL	6.9363 mL	17.3406 mL
	15 mM	0.4624 mL	2.3121 mL	4.6242 mL	11.5604 mL
	20 mM	0.3468 mL	1.7341 mL	3.4681 mL	8.6703 mL
	25 mM	0.2775 mL	1.3873 mL	2.7745 mL	6.9363 mL
	30 mM	0.2312 mL	1.1560 mL	2.3121 mL	5.7802 mL
	40 mM	0.1734 mL	0.8670 mL	1.7341 mL	4.3352 mL
	50 mM	0.1387 mL	0.6936 mL	1.3873 mL	3.4681 mL
	60 mM	0.1156 mL	0.5780 mL	1.1560 mL	2.8901 mL
	80 mM	0.0867 mL	0.4335 mL	0.8670 mL	2.1676 mL
	100 mM	0.0694 mL	0.3468 mL	0.6936 mL	1.7341 mL